An unusual way to synthesize 1-nitronaphthalene from 1-amino-5-nitronaphthalene
نویسندگان
چکیده
منابع مشابه
Bioassay of 1-nitronaphthalene for possible carcinogenicity.
A bioassay of technical-grade 1-nitronaphthalene for possible carcinogenicity was conducted using Fischer 344 rats and B6C3F1 mice. 1-Nitronaphthalene was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. The high and low time-weighted average concentrations used in the chronic study were, respectively, 0.18 and 0.06 percent f...
متن کاملBioactivation of the pulmonary toxicants naphthalene and 1-nitronaphthalene by rat CYP2F4.
Naphthalene, a ubiquitous environmental contaminant, produces cytotoxicity in nonciliated bronchiolar epithelial (Clara) cells in mice; rats are refractory to lung cytotoxicity from naphthalene. In contrast, 1-nitronaphthalene is a potent toxicant in both species. Naphthalene is metabolized by CYP2F to a 1,2-epoxide, the first and obligate step in events leading to cytotoxicity. 1-Nitronaphthal...
متن کاملPhotochemical and photosensitised reactions involving 1-nitronaphthalene and nitrite in aqueous solution.
The excited triplet state of 1-nitronaphthalene, 1NN, ((3)1NN) is able to oxidise nitrite to ˙NO(2), with a second-order rate constant that varies from (3.56 ± 0.11) × 10(8) M(-1) s(-1) (μ±σ) at pH 2.0 to (3.36 ± 0.28) × 10(9) M(-1) s(-1) at pH 6.5. The polychromatic quantum yield of ˙NO(2) photogeneration by 1NN in neutral solution is Φ(˙NO(2))(1NN)≥ (5.7 ± 1.5) × 10(7)× [NO(2)(-)]/{(3.4 ± 0.3...
متن کاملSite-specific metabolism of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques.
Studies in rodents have demonstrated the importance of cytochrome P450 monooxygenases in generating reactive metabolites that produce Clara cell injury. Pulmonary P450 activities in rodents are much higher than those in primates, raising the issue of relevance of rodent data to primates. Few studies on P450-catalyzed activation of cytotoxicants in subcompartments of primate lung have been repor...
متن کاملLong-term exposure to ozone increases acute pulmonary centriacinar injury by 1-nitronaphthalene: II. Quantitative histopathology.
Long-term exposure to the oxidant air pollutant ozone (O(3)) is associated with tolerance to the acute effects of oxidant injury. To test whether this resistance to acute injury extends to bioactivated pulmonary toxicants, male Sprague-Dawley rats were exposed to filtered air (FA) or 0.8 ppm O(3) (8 h/day) for 90 days and administered 1-nitronaphthalene i.p. at doses of 0, 50, or 100 mg/kg. 1-N...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: African Journal of Pharmacy and Pharmacology
سال: 2011
ISSN: 1996-0816
DOI: 10.5897/ajpp11.070